6533b7d0fe1ef96bd125af1f

RESEARCH PRODUCT

Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity

Norbert SewaldAngelbert F. AwantuJean Jules Kezetas BankeuHardo Suzy Donfack ChounaHardo Suzy Donfack ChounaSilvère Augustin NgouelaSilvère Augustin NgouelaGabin Thierry M. BitchagnoYannick Stéphane Fotsing FongangDarline DizeBeaudelaire Kemvoufo PonouFabrice Boyom FekamTill OpatzBruno Ndjakou Lenta

subject

Antiparasiticmedicine.drug_classLeishmania donovaniPeperomia vulcaniaPlant Science01 natural sciencesBiochemistryAntiplasmodialmedicineAntileishmanialCytotoxicityIC50biologyTraditional medicine010405 organic chemistryChemistryPeperomia vulcanicaPlasmodium falciparumPeperotanninPiperaceaePiperaceaebiology.organism_classificationPeperolignanIn vitro0104 chemical sciences010404 medicinal & biomolecular chemistryAgronomy and Crop ScienceBiotechnology

description

Abstract The investigation of the CH2Cl2-MeOH (1:1) extract of Peperomia vulcanica which showed antileishmanial activity during preliminary screening led to the isolation of two previously unknown compounds named peperolignan (1) and peperotannin (2) along with 13 known compounds. Their structures were determined on the basis of their spectroscopic data. The isolated compounds were assessed in vitro for their antileishmanial and antiplasmodial activities against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes and the Plasmodium falciparum chloroquine-sensitive 3D7 strain (Pf3D7), respectively. They were also assessed for their cytotoxicity on Raw 264.7 macrophage cells. The mixture of 4-hydroxy-2-[(3,4-methylenedioxyphenyl)nonanoyl]cyclohexan-1,3-dione and 4-hydroxy-2-[(3,4-methylenedioxyphenyl) undecanoyl] cyclo-hexane-1,3-dione (10a and 10b) exhibited potent antiplasmodial activity (IC50 = 0.35 μg/mL) with selectivity index higher than 10-fold (SI = 63.4) and moderate leishmanicidal activity (IC50 = 12.17 μg/mL) with very low selectivity index (SI = 1.82). The obtained results could provide an extent of validation to the traditional uses of Peperomia vulcanica for the treatment of malaria in endemic areas.

yearjournalcountryeditionlanguage
2021-02-01Phytochemistry Letters
https://doi.org/10.1016/j.phytol.2020.10.010