Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-l-Trp-l-Pro

6533b7d0fe1ef96bd125af30

RESEARCH PRODUCT

Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-l-Trp-l-Pro

Robert M. Williams Takeo Usui Emily M. Stocking Hiroyuki Osada Juan F. Sanz-cervera

subject

Indoles Stereochemistry Clinical Biochemistry Protein Prenylation Mitosis Pharmaceutical Science Microtubules Peptides Cyclic Biochemistry Chemical synthesis Piperazines Indole Alkaloids Microtubule Drug Discovery medicine Animals Fibroblast Cytotoxicity Molecular Biology Cells Cultured chemistry.chemical_classification Molecular Structure Chemistry Organic Chemistry Biological activity Fibroblasts In vitro Cyclic peptide Rats medicine.anatomical_structure Biochemistry Cell culture Molecular Medicine Cattle Microtubule-Associated Proteins

description

The synthesis of three isoprenylated derivatives of cyclo-L-Trp-L-Pro is described. These substances have been evaluated for cytotoxic activity in rat normal fibroblast 3Y1 cells and have also been evaluated in vitro for the inhibition of microtubule assembly.

year	journal	country	edition	language
2000-10-01	Bioorganic & Medicinal Chemistry

https://doi.org/10.1016/s0968-0896(00)00171-1

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