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RESEARCH PRODUCT
8-Iodonaphthalene-1-carbaldehyde: A Versatile Building Block for Diversity-Oriented Synthesis.
Pablo BarrioIgnacio IbáñezLidia HerreraSantos FusteroNatalia MateuRaquel Románsubject
010405 organic chemistryChemistryOrganic ChemistryImine010402 general chemistry01 natural sciencesBiochemistryCombinatorial chemistryChemical space0104 chemical scienceschemistry.chemical_compoundBlock (programming)Organic chemistryPhysical and Theoretical Chemistrydescription
The scarcely studied 8-halonaphthalene-1-carbaldehyde structure has been converted into the corresponding Ellman’s imine and subjected to several transformations, thus achieving an assorted library of polycyclic carbo- and heterocycles. The potential of this scaffold for Diversity-Oriented Synthesis has been shown. Most of these skeletons are unprecedented and, therefore, cover unexplored regions of the chemical space.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-09-01 | Organic letters |