6533b7d0fe1ef96bd125b6ed
RESEARCH PRODUCT
The Anaphylatoxic Peptide C3a of Guinea Pig Complement
Stefan BeckerDieter Bitter-suermannStefan MeuerUlrich Haddingsubject
chemistry.chemical_classificationbiologyChemistrychemical and pharmacologic phenomenaPeptideGeneral MedicineCleavage (embryo)TrypsinMolecular biologyCarboxypeptidaseGuinea pigIsoelectric pointEnzymeBiochemistryAlternative complement pathwaymedicinebiology.proteinmedicine.drugdescription
Abstract Highly purified guinea pig C3a was obtained after specific cleavage of isolated C3 by the alternative pathway enzyme VF-B in a one step procedure. It turned out to be a low molecular weight peptide with basic character (M.W. 9500; isoelectric point above 9.4). C3a represents an antigenetic determinant of its own in the native C3 molecule, different from the B determinant. Guinea pig C3a is resistant to 100°C for 10 minutes. Its smooth muscle contracting activity can be destroyed by trypsin and carboxypeptidase B. These findings indicate that guinea pig C3a is quite similar to human C3a.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1978-03-01 | Zeitschrift für Immunitätsforschung: Immunobiology |