A NANOPARTICULATE DRUG-DELIVERY SYSTEM FOR RIVASTIGMINE: PHYSICO-CHEMICAL AND IN VITRO BIOLOGICAL CHARACTERIZATION

6533b7d1fe1ef96bd125be93

RESEARCH PRODUCT

A NANOPARTICULATE DRUG-DELIVERY SYSTEM FOR RIVASTIGMINE: PHYSICO-CHEMICAL AND IN VITRO BIOLOGICAL CHARACTERIZATION

Craparo Emanuela Fabiola Pitarresi Giovanna Bondì Maria Luisa Casaletto Maria Pia Licciardi Mariano Giammona Gaetano

subject

Molecular Structure Cell Survival Ultraviolet Rays Phenylcarbamates Rivastigmine Hemolysis Polyethylene Glycols POLYMERIC NANOPARTICLES RIVASTIGMINE DRUG DELIVERY Drug Delivery Systems Polymethacrylic Acids Settore CHIM/09 - Farmaceutico Tecnologico Applicativo Cell Line Tumor Delayed-Action Preparations Humans Nanoparticles Peptides Triacetin

description

The preparation and characterization of surface-PE Gylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM-PEG(2000) as an inverse microemulsion, using an aqueous solution of the PHM/PHM-PEG(2000) copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta-potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug-release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.

year	journal	country	edition	language
2007-11-28

http://hdl.handle.net/10447/37864

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