6533b7d1fe1ef96bd125c0d9
RESEARCH PRODUCT
Preparation of 5‐bromo‐6‐phenylimidazo[2,1‐b][1,3,4]thiadiazol‐2‐ylamines
Rahmonov RahmonHerbert MeierSaifidin SafarovElena KarpukDieter SchollmeyerMuhamacho Amadovich Kukanievsubject
chemistry.chemical_compoundPrimary (chemistry)chemistryOrganic ChemistryHydrazineSubstituentCrystal structureMedicinal chemistrydescription
The reaction of primary or secondary amines with 2,5-dibromo-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole (5) leads to a chemoselective replacement of the 2-Br substituent. The process represents a convenient route to the corresponding 2-ylamines 7a-d. Hydrazine reacts in an analogous fashion (5 → 7e). The structure determinations are based on an X-ray crystal structure analysis and on one- and two-dimensional NMR measurements.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-01 | Journal of Heterocyclic Chemistry |