Uz hialuronskābes bāzes veidotu funkcionalizētu biomateriālu efektivitātes un drošības izvērtējums in vivo brūču modelī

6533b7d1fe1ef96bd125c631

RESEARCH PRODUCT

Uz hialuronskābes bāzes veidotu funkcionalizētu biomateriālu efektivitātes un drošības izvērtējums in vivo brūču modelī

Katrīna Jukēvica

subject

in vivo brūču modeļi imunomodulatori brūču dzīšana Farmācija glikoproteīni

description

Joprojām ir aktuāla dzīšanu stimulējošu, jaunu funkcionālu biomateriālu izveide, lai nodrošinātu ātrāku un efektīvāku brūču dzīšanas procesu klīnikā. Maģistra darbā tika izvērtēti jaunizveidotie biomateriāli, kas ietver glikoproteīnu, efektivitāte brūču dzīšanas procesos Wistar žurku tēviņiem un veikti akūtas toksicitātes noteikšanas pētījumi C57BL/6 līnijas peļu tēviņiem. Iegūtie rezultāti uz brūču dzīšanas procesu apstiprina jaunizveidoto biomateriālu (1 un 2) efektivitāti un progresīvu dinamiku brūču dzīšanas procesos, jau sākot ar pētījuma ceturto dienu, salīdzinot ar kontroles grupas rezultātiem. Pēc lielu devu intraperitoneālas ievadīšanas dabīgais imunomodulators uzrāda drošību akūtas toksikoloģijas novērtējumā, jo neizraisa iekaisuma reakciju, nozīmīgas svara un temperatūras izmaiņas C57BL/6 līnijpelēm.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/30810

PEPhysical Sciences and Engineering
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