6533b7d1fe1ef96bd125caae

RESEARCH PRODUCT

Bis-cyclohexyl-crown-ethers as allosteric carriers

Ana M. CosteroSantiago Rodriguez

subject

MembraneChemistryBiological modelingOrganic ChemistryDrug DiscoveryAllosteric regulationCrown (botany)Polymer chemistryIonophoreOrganic chemistryCooperativityBiochemistryCation transport

description

Abstract Several bis-cyclohexyl-crown-ethers have been synthesized and used as carriers for alkaline cations. These compounds should all show negative allosteric cooperativity, but only 1 exhibits an odd cation transport behavior across the liquid organic membranes.

https://doi.org/10.1016/s0040-4020(01)88218-1