6533b7d1fe1ef96bd125cbca

RESEARCH PRODUCT

ChemInform Abstract: Synthesis of Fluorinated and Non-Fluorinated Bicyclic Amidines Through Ring-Closing Metathesis.

Santos FusteroJudit OliverSonia FloresAna C. Cuñat

subject

Ring-closing metathesisBicyclic moleculeChemistryCondensationSalt metathesis reactionGeneral MedicineMedicinal chemistry

description

Condensation of unsaturated esters (I) and (VII) with 1,2-diamines proceeds in the presence of trimethylaluminum providing imidazolines (III) and (VIII) which are further allylated giving suitable dienes (V) and (IX).

https://doi.org/10.1002/chin.201220119