6533b7d1fe1ef96bd125cdfb
RESEARCH PRODUCT
Liver regeneration induced by a designer human IL‐6/ sIL‐6R fusion protein reverses severe hepatocellular injury
Stefan Rose-johnOrit PappoEithan GalunEvelyn ZeiraMalte Peterssubject
MalePathologymedicine.medical_specialtyRecombinant Fusion Proteinsmedicine.medical_treatmentApoptosisGalactosamineThioacetamideBiochemistryFulminant hepatic failureGeneticsmedicineAnimalsHumansReceptorInterleukin 6Molecular BiologybiologyInterleukin-6ChemistryLiver cellRegeneration (biology)Receptors InterleukinReceptors Interleukin-6Fusion proteinRats Inbred F344Liver regenerationLiver RegenerationRatsDisease Models AnimalCytokineCancer researchbiology.proteinCell DivisionLiver FailureBiotechnologydescription
The cytokine IL-6 plays a significant role in liver regeneration in conjunction with additional growth factors (HGF, TNF-α, and TGF-α). Many IL-6 effects depend on a naturally occurring soluble IL-6 receptor (sIL-6R). Here, the chimeric protein hyper-IL-6, constructed from the human IL-6 protein fused to a truncated form of its receptor, was found to have superagonistic IL-6 properties, and as such, enhanced liver cell regeneration. Hyper-IL-6 reversed the state of hepatotoxicity and enhanced the survival rates of rats suffering from fulminant hepatic failure after D-galactosamine administration. The hyper-IL-6 protein has a significant potential for use in the treatment of severe human liver diseases.—Galun, E., Zeira, E., Pappo, O., Peters, M., Rose-John, S. Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-10-12 | The FASEB Journal |