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RESEARCH PRODUCT

Analytical Methods Used in Biotransformation Studies of Organophosphonates

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This work was supported by the National Science Centre, Poland (NCN) grant number 2017/27/B/NZ4/00698. Among diverse organophosphorus compounds, whose residues are determined in various ecosystems, phosphonates possess special meaning. Regarding their biological activity, capability to chelating metal cations, and stability of direct carbon to phosphorus bond under physiological conditions, phosphonic compounds found many various applications. These compounds are commonly used as pesticides, drugs, anticorrosive agents, and additives to surfactants. Common use of these substances results in an increase in their concentration in various ecosystems which may cause considerable ecological problems. Because xenobiotics in the environment are exposed to the action of biotic and abiotic factors that usually leads to their structural changes, it is important to track their fate there. Phosphonic derivatives may be determined (qualitatively and quantitatively) using various specific analytical methods, particularly spectrometry and chromatography; however, analyzing these compounds in environmental samples is still a challenge, which we try to express in this chapter.