Florizīna un metformīna farmakoloģisko efektu salīdzinājums in vitro

6533b7d1fe1ef96bd125d0fd

RESEARCH PRODUCT

Florizīna un metformīna farmakoloģisko efektu salīdzinājums in vitro

Amanda ŠKapare

subject

antioksidanti dziļas glikēšanas beigu produkti metformīns Farmācija florizīns

description

Florizīns ir dabā sastopams polifenols ar pretdiabēta iedarbību. Metformīns ir visplašāk lietotais pretdiabēta līdzeklis. Cukura diabēta gadījumā ir palielināta brīvo radikāļu ražošana, traucētas endogēno antioksidantu aizsargspējas un pieaug glikēto proteīnu daudzums. Tāpēc antioksidantu efektu pētīšana ir tikpat svarīga kā glikozes līmeņa kontrole asinīs diabēta ārstēšanā. Maģistra darbā tika pētīti florizīna un metformīna antioksidantu un dziļās glikēšanas beigu produktu (AGE) inhibīcijas efekti in vitro. Rezultāti liecina, ka abām vielām piemīt antioksidantu īpašības DPPH testā, bet ne tik spēcīgi kā askorbīnskābei. Florizīns un askorbīnskābe uzrāda superoksīda dismutāzei līdzīgas īpašības, bet metformīnam šādas īpašības netika novērotas. Askorbīnskābe, florizīns un metformīns inhibē AGE veidošanos.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54659

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