6533b7d1fe1ef96bd125d54d
RESEARCH PRODUCT
ChemInform Abstract: Gold-Catalyzed Povarov-Type Reaction of Fluorinated Imino Esters and Furans.
Santos FusteroCarlos Del PozoJavier MiróMaría Sánchez-rosellóAlvaro Sanz-vidalsubject
ChemistryGeneral MedicinePovarov reactionCombinatorial chemistryCatalysisdescription
A gold-catalyzed Povarov-type reaction of fluorinated imino esters and furans is described. The process, which takes place in dichoromethane at room temperature, gives rise to novel fluorinated tetrahydrofuran-fused tetrahydroquinolines in good yields and moderate levels of diastereoselectivity in a very simple manner. The reported examples expand the versatility of the Povarov reaction to unprecedented fluorinated substrates, generating scaffolds that contain quaternary α-amino acid units.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-12-01 | ChemInform |