6533b7d1fe1ef96bd125d779
RESEARCH PRODUCT
Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes
Johannes M. WiestJohannes M. WiestAlexander Sandvoßsubject
Molecular complexity010405 organic chemistryChemistryOrganic Chemistryoxetaneoxygen heterocyclesEnantioselective synthesisMinireviewsContext (language use)General ChemistryStrain relief010402 general chemistry01 natural sciencesCombinatorial chemistryDesymmetrizationCatalysis0104 chemical sciencesdesymmetrizationstrained moleculesMinireviewLewis acids and basesAsymmetric Synthesisdescription
Abstract Strain relief of oxetanes offers a plethora of opportunities for the synthesis of chiral alcohols and ethers. In this context, enantioselective desymmetrization has been identified as a powerful tool to construct molecular complexity and this has led to the development of elegant strategies on the basis of transition metal, Lewis acid, and Brønsted acid catalysis. This review highlights recent examples that harness the inherent reactivity of prochiral oxetanes and offers an outlook on the immense possibilities for synthetic application.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-02 | Chemistry – A European Journal |