Synthesis and structure of mono-bridged resorcinarene host: a ditopic receptor for ammonium guests.

6533b7d1fe1ef96bd125d840

RESEARCH PRODUCT

Synthesis and structure of mono-bridged resorcinarene host: a ditopic receptor for ammonium guests.

Kirsi Salorinne Tiia-riikka Tero Maija Nissinen Kaisa Riikonen

subject

Models Molecular Magnetic Resonance Spectroscopy Stereochemistry Phenylalanine Molecular Conformation Biochemistry chemistry.chemical_compound Polymer chemistry medicine Hydroxides Moiety Physical and Theoretical Chemistry Crown ether chemistry.chemical_classification Tetramethylammonium Binding Sites Organic Chemistry Nuclear magnetic resonance spectroscopy Resorcinarene Crown Compounds Quaternary Ammonium Compounds chemistry Proton NMR Titration Calixarenes Acetylcholine medicine.drug

description

The synthesis and structural properties of tetramethoxy resorcinarene mono-crown-5 (1) are described. The binding characteristics of 1 toward acetylcholine and tetramethylammonium salts were investigated by 1H NMR titration. It was observed that the cavity of 1 provides a better fit to acetylcholine compared to the smaller tetramethylammonium cation, as acetylcholine is able to interact with both the crown ether moiety and the free hydroxyl groups of receptor 1 simultaneously.

year	journal	country	edition	language
2009-10-02	Organicbiomolecular chemistry

10.1039/b911389d https://pubmed.ncbi.nlm.nih.gov/19795059

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