6533b7d1fe1ef96bd125d8e7
RESEARCH PRODUCT
The Recent Crystal Structure of Human Tyrosinase Related Protein 1 (HsTYRP1) Solves an Old Problem and Poses a New One
Heinz DeckerFelix Tuczeksubject
Protein ConformationTyrosinasechemistry.chemical_elementNanotechnologyZincCrystallography X-Ray010402 general chemistry01 natural sciencesAntioxidantsCatalysisMelaninProtein structureCatalytic DomainHumansTYRP1MelanosomeMelaninschemistry.chemical_classificationMembrane Glycoproteinsbiology010405 organic chemistryActive siteGeneral ChemistryCombinatorial chemistry0104 chemical sciencesZincEnzymechemistrybiology.proteinTyrosineOxidoreductasesCopperdescription
Show your metal: l-Tyrosine is converted into the protective antioxidative polymer melanin in a sequence of reactions. In humans, the catalytic pathway starts with the tyrosinase HsTYR and two tyrosinase-related proteins HsTYRP1 and HsTYRP2. All three enzymes have the same active site but the latter two contain two zinc ions instead of copper ions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-08-10 | Angewandte Chemie International Edition |