6533b7d2fe1ef96bd125e0dd
RESEARCH PRODUCT
Evolution of oncolytic viruses.
Rafael SanjuánValery Z. Grdzelishvilisubject
Replicative capacityGeneticsOncolytic VirotherapyExperimental evolutionNatural selectionExtramuralNeoplasms therapyComputational biologyBiologyDirected evolutionOncolytic virusEvolution MolecularOncolytic VirusesVirologyNeoplasmsAnimalsHumansdescription
Owing to their replicative capacity, oncolytic viruses (OVs) can evolve under the action of natural selection. Reversion to virulence and recombination with wild-type strains may compromise OV safety, therefore requiring evolutionary risk assessment studies. On the other hand, evolution can be directed in the laboratory to create more potent and safer OVs. Previous work in the experimental evolution field provides a background for OV directed evolution, and has identified interesting exploitable features. While genetic engineering has greatly advanced the field of oncolytic virotherapy, this approach is sometimes curtailed by the complexity and diversity of virus-host interactions. Directed evolution provides an alternative approach that may help to obtain new OVs without prejudice toward the underlying molecular mechanisms involved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-08-01 | Current opinion in virology |