PROTACs: The Future of Leukemia Therapeutics

6533b7d2fe1ef96bd125e2c0

RESEARCH PRODUCT

PROTACs: The Future of Leukemia Therapeutics

Zubair Anwar Muhammad Shahzad Ali Antonio Galvano Alessandro Perez Maria La Mantia Ihtisham Bukhari Bartlomiej Swiatczak

subject

PROTACs leukemia cancer anticancer therapeutics Cell Biology linker Developmental Biology

description

The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various types of Leukemia/Blood malignancies.

year	journal	country	edition	language
2022-09-02	Frontiers in Cell and Developmental Biology

10.3389/fcell.2022.851087 http://dx.doi.org/10.3389/fcell.2022.851087

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