6533b7d2fe1ef96bd125e8e4
RESEARCH PRODUCT
Synthesis of spongian diterpenes: (−)-spongian-16-oxo-17-al and (−)-acetyldendrillol-1
Ramón J. ZaragozáManuel ArnóMiguel A. GonzálezM. Luisa Marinsubject
ChemistryStereochemistryOrganic ChemistryDrug DiscoveryAbsolute configurationSpongian-16-oxo-17-alBiochemistryAcetyldendrillol-1description
Abstract An efficient diastereoselective synthesis of the spongian diterpenes (−)-spongian-16-oxo-17-al ( 1 ) and (−)-acetyldendrillol-1 ( 13 ) is described starting from (+)-podocarp-8(14)-13-one ( 6 ) via the ester-dialdehyde 11 as key intermediate. The absolute configuration at C-17 in synthetic compound 13 has conclusively been proved by NOE experiments.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-02-01 | Tetrahedron Letters |