6533b7d2fe1ef96bd125e9e1
RESEARCH PRODUCT
ChemInform Abstract: Novel Strategy for the Synthesis of Fluorinated β-Amino Acid Derivatives from Δ2-Oxazolines.
Belén PinaSantos FusteroAmparo AsensioCarmen Ramírez De ArellanoEsther Salavertsubject
chemistry.chemical_classificationchemistryOrganic chemistryGeneral MedicineChemoselectivityAmino aciddescription
Abstract Racemic and chiral non-racemic β-fluoroalkyl-β-amino acid derivatives have been prepared in two steps starting from 2-alkyl-Δ2-oxazolines and fluorinated imidoyl chlorides. Subsequent chemoselective reduction of the C-masked β-enamino acid derivatives initially formed provided the target β-amino acids. The process takes place with total chemoselectivity, high yields and satisfactory diastereoselectivity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-23 | ChemInform |