6533b7d2fe1ef96bd125e9ef

RESEARCH PRODUCT

Asymmetric Synthesis of Five-Membered Spiropyrazolones via N-Heterocyclic Carbene (NHC)-Catalyzed [3+2] Annulations

Lei WangKari RissanenAnssi PeuronenSun LiDieter EndersPankaj Chauhan

subject

chemistry.chemical_compoundchemistry010405 organic chemistryStereochemistryOrganic ChemistryEnantioselective synthesisPyrazolones010402 general chemistry01 natural sciencesCarbeneCatalysis0104 chemical sciencesCatalysis

description

A new synthetic strategy for the asymmetric synthesis of five-membered spiropyrazolones via N-heterocyclic carbene-catalyzed [3+2] annulations employing enals and unsaturated pyrazolones as substrates has been developed. The new protocol allows the flexible variation of all four substituents of the pharmaceutically important spiropyrazolones in moderate to very good yields and in most cases with excellent diastereoselectivities and good to excellent enantioselectivities.

yearjournalcountryeditionlanguage
2016-12-20Synthesis
https://doi.org/10.1055/s-0036-1588381