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RESEARCH PRODUCT

Additional file 3: of Evolutionary stability of topologically associating domains is associated with conserved gene regulation

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Figure S3. Distance between rearrangement breakpoints and random controls to closest TAD boundary. For each species (y-axis) and fill size threshold (vertical panels) the distances from all identified rearrangement breakpoints to its closest TAD boundary (x-axis) are compared between actual rearrangements (blue) and 100 times randomized background controls (gray). The left panel shows distances to next hESC TAD boundary and the right panel distances to closest GM12878 contact domain boundary. P-values according to Wilcoxonâ s rank-sum test. (PDF 14 kb)