6533b7d2fe1ef96bd125ebb1
RESEARCH PRODUCT
Overexpression of Bcl-3 inhibits the development of marginal zone B cells.
Ari WaismanMatthias HahnMarcus A. WörnsSonja ReissigJennifer LeclaireAlexei NikolaevSimone WörtgePeter R. GallePetra Adams-quackNadine Hövelmeyersubject
B-LymphocytesCell growthImmunologyGerminal centerGene ExpressionNF-κBBiologyMarginal zoneGerminal CenterMolecular biologyCell biologychemistry.chemical_compoundMiceImmune systemchemistryApoptosisB-Cell Lymphoma 3 ProteinProto-Oncogene ProteinsMarginal zone B-cellImmunology and AllergyAnimalsTranscription factorCell ProliferationTranscription Factorsdescription
The transcription factor Bcl-3 functions as a proto-oncogene via regulation of cell proliferation and apoptosis. Bcl-3 is an atypical member of the IκB family and plays a central role in the immune response through interactions with the NF-κB subunits p50 and p52. To investigate the impact of Bcl-3 on B-cell maturation and regulation, we generated mice that overexpress Bcl-3 specifically in B cells. Interestingly, these mice lack marginal zone B cells and exhibit a significant reduction in the number of B-1 B cells. Further, B cells from these mice are impaired in their proliferative capacity. Our data demonstrate that the overexpression of the transcription factor Bcl-3 inhibits germinal center formation, marginal zone B-cell development, and affects the B-1 B-cell compartment.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-11-18 | European journal of immunology |