6533b7d2fe1ef96bd125ec38
RESEARCH PRODUCT
Characteristics and survival of patients with primary biliary cholangitis and hepatocellular carcinoma
Edoardo G. GianniniGiulia PieriSara LabancaMaria Corina Plaz TorresAntonio GasbarriniElisabetta BiasiniClaudia CampaniNora CazzagonFrancesco Giuseppe FoschiAndrea MegaAlberto MasottoGiovanni RaimondoGian Ludovico RapacciniRodolfo SaccoEugenio CaturelliMaria GuarinoFrancesco TovoliGianpaolo VidiliMaurizia Rossana BrunettoGerardo NardoneGianluca Svegliati-baroniDonatella MagalottiFrancesco AzzaroliGiuseppe CabibboMaria Di MarcoAngelo SangiovanniFranco TrevisaniMaurizio BiselliPaolo CaraceniAnnagiulia GramenziFrancesca BeneventoAlessandro GranitoLuca MuratoriFabio PiscagliaFederica BertelliniFabio FarinatiGiorgio PalanoFilippo PelizzaroBarbara PenzoElisa PintoGloria AllegriniCalogero CammàCiro CelsaPaolo GiuffridaCaterina StornelloMauro GrovaCarmelo Marco GiacchettoGabriele RancatoreMaria Vittoria GrassiniValentina AdottiStefano GittoFabio MarraMartina RosiVittoria BevilacquaAlberto BorghiAndrea Casadei GardiniFabio ContiLucia NapoliMarco DomenicaliMaria Teresa MiglianoNicoletta De MatthaeisFrancesca Romana PonzianiAndrea OlivaniGabriele MissaleValentina CossigaMario CapassoFilomena MoriscoEster Marina CelaAntonio FacciorussoValentina LauriaGiorgia GhittoniGiorgio PeleccaFabrizio ChegaiFabio CoratellaMariano OrtenziSerena Dell'isolaMaria Stella FranzèCarlo SaittaAssunta SauchellaElton DajtiFederico RavaioliFilippo OliveriGabriele RiccoVeronica RomagnoliAlessandro InnoFabiana MarchettiPietro CoccoliAntonio MalerbaAlberta CappelliRita GolfieriCristina MosconiMatteo Renzullisubject
MaleCarcinoma HepatocellularCholestatic liver disease; Outcome; Surveillance; Survival; TreatmentSurveillanceHepatologySurvivalPrognosiLiver Cirrhosis BiliaryRisk FactorSettore MED/12 - GASTROENTEROLOGIALiver NeoplasmsGastroenterologyCholestatic liver diseasePrognosisTreatmentRisk FactorsHumansFemaleTreatment.HumanAgedOutcomedescription
Background: Comprehensive and contemporary data pertaining large populations of patients with Primary Biliary Cholangitis (PBC) and hepatocellular carcinoma (HCC) are missing. Aim: To describe main characteristics and outcome of PBC patients with HCC diagnosed in the new millennium. Methods: Analysing the Italian Liver Cancer registry we identified 80 PBC patients with HCC diagnosed after the year 2000, and described their clinical characteristics, access to treatment and survival. Results: Median age of patients was 71 years and 50.0% were males. Cirrhosis was present in 86.3% of patients, being well-compensated in 58.0%. Median HCC diameter was smaller in patients under surveillance (2.6 vs 4.0 cm, P = 0.007). Curative treatment, feasible in 50.0% of patients, was associated with improved survival compared to palliative and supportive care (42 vs 33 vs 6 months, P<0.0001). Surveillance was associated with a non-significant improved survival (36 vs 23 months), likely due to similar rate of curative treatment in patients under (51.4%) and outside surveillance (42.6%). Conclusions: PBC patients with HCC are often elderly males with well-preserved liver function. Feasibility of curative treatment is high and associated with improved prognosis. Description of these patients may help focus surveillance to identify earlier tumours, increase their curability, and improve prognosis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-09-01 |