6533b7d2fe1ef96bd125ecb6

RESEARCH PRODUCT

Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

Paola BarrajaCristina CianciminoVirginia SpanòAnna CarboneGirolamo CirrincioneAlessandra MontalbanoBarbara ParrinoPatrizia Diana

subject

Isoindolo[15]benzoxazepineChemistryStereochemistryDrug Discovery3003 Pharmaceutical ScienceOrganic Chemistry5]benzoxazepine4]benzoxazinoneAntiproliferative activityRing (chemistry)Settore CHIM/08 - Chimica FarmaceuticaBiochemistryHuman tumorchemistry.chemical_compoundIsoindolo[14]benzoxazinoneDrug DiscoveryIsoindolo[1Antiproliferative activity; Isoindole; Isoindolo[1; 4]benzoxazinone; Isoindolo[1; 5]benzoxazepine; Biochemistry; Organic Chemistry; Drug Discovery3003 Pharmaceutical ScienceIsoindoleIsoindole

description

Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI 50 mean values at low micromolar level (3.72–5.13 μM).

yearjournalcountryeditionlanguage
2015-09-01
10.1016/j.tet.2015.04.083http://hdl.handle.net/11567/1024145