6533b7d2fe1ef96bd125ecbe

RESEARCH PRODUCT

Synthesis, chemical characterization and preliminary in vitro antitumor activity evaluation of new ruthenium(II) complexes with sugar derivatives

Girolamo CasellaMichele AbbateClaudia PelleritoFrancesco FerranteAlessandro LongoGianfranco Fontana

subject

Antitumor activityCarbohydrates Anti-cancer Melanoma A375Extended X-ray absorption fine structureMetastatic melanomaStereochemistrychemistry.chemical_elementSulfoxideMedicinal chemistryIn vitroRutheniumInorganic ChemistrySugar derivativeschemistry.chemical_compoundchemistryElemental analysisMaterials ChemistryPhysical and Theoretical Chemistry

description

Abstract Three new complexes of Ru(II), namely [RuCl 2 (Glun-N,O) 2 ]Na 2 ( I ; Glun = glucosaminate), [RuCl 2 (1-Tglu)(EtOH) 2 ]Na ( II ; 1-Tglu = 1-thio-β- d -glucose) and [Ru 2 (EtOH) 6 (AL)Cl 4 ] ( III ; AL = 6′-aminolactose) were prepared from the same Ru(II) precursor, [RuCl 2 (DMSO) 4 ] (DMSO = dimethyl sulfoxide). The characterization of the complexes was carried out by elemental analysis, FT-IR, ES-MS, NMR, EXAFS and DFT calculations. The effectiveness of the complexes on metastatic melanoma A 375 was investigated. The results show that complex II is the most active species.

yearjournalcountryeditionlanguage
2011-06-01
http://hdl.handle.net/10447/74651