6533b7d2fe1ef96bd125edd2

RESEARCH PRODUCT

Selective, Highly Sensitive, and Rapid Detection of Genomic DNA by Using Gated Materials:MycoplasmaDetection

Ramón Martínez-máñezLaura MondragónFélix SancenónEnrique Pérez-payáKnut RurackJosé Ramón MurguíaPedro AmorósEstela ClimentM. Dolores Marcos

subject

DNA BacterialINGENIERIA DE LA CONSTRUCCIONSupportsMesoporous silica nanoparticlesFermentansResponsive controlled releaseAmplificationmesoporous materialsBiologysensorsmedicine.disease_causeRapid detectionCatalysisgated materialschemistry.chemical_compoundMycoplasmaQUIMICA ORGANICAContaminationQUIMICA ANALITICABIOQUIMICA Y BIOLOGIA MOLECULARmedicineGated materialsRheumatoid arthritismycoplasmaControlled drug deliverySensorsQUIMICA INORGANICAGenomicsDNAGeneral ChemistryMycoplasmaCell culturesMolecular biologyHighly sensitivegenomic DNAchemistryDNA

description

The coupling of gated-indicator delivery with highly specific biochemical recognition is an innovative strategy for the detection of DNA sequences, able to compete with classical methods which need PCR amplification, in important areas such as point-of-care diagnostics or detection of specific biological contaminations with pathogens. Such comparatively simple and cheap yet highly selective and sensitive assays hold promise for use in less-developed areas of the world.

https://doi.org/10.1002/anie.201302954