6533b7d2fe1ef96bd125f4f4
RESEARCH PRODUCT
Molecular evolution methods to study HIV-1 epidemics
Fernando González-candelasJuan ÁNgel Patiño-galindosubject
0301 basic medicinemedicine.medical_specialtyMolecular epidemiologyPublic healthHuman immunodeficiency virus (HIV)HIVComputational biologyBiologymedicine.disease_causePhylogenetics03 medical and health sciences030104 developmental biologyPhylogeneticsMolecular evolutionVirologyMolecular epidemiologyEpidemiologymedicineTransmission clusterSpecial Reportdescription
Nucleotide sequences of HIV isolates are obtained routinely to evaluate the presence of resistance mutations to antiretroviral drugs. But, beyond their clinical use, these and other viral sequences include a wealth of information that can be used to better understand and characterize the epidemiology of HIV in relevant populations. In this review, we provide a brief overview of the main methods used to analyze HIV sequences, the data bases where reference sequences can be obtained, and some caveats about the possible applications for public health of these analyses, along with some considerations about their limitations and correct usage to derive robust and reliable conclusions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |