6533b7d2fe1ef96bd125f564

RESEARCH PRODUCT

Dosimetric feasibility study for an extracorporeal BNCT application on liver metastases at the TRIGA Mainz

Matthias BlaicknerHeinz SchmidbergerG. HampelJens Volker KratzS. MinouchehrGerd OttoL. VogtländerB. WortmannC. Schütz

subject

Radiationbusiness.industryLiver NeoplasmsBoron Neutron Capture TherapyRadiotherapy DosageModels BiologicalExtracorporealTRIGANeutron captureMonte carlo codeLiver tissueHumansMedicineComputer SimulationRadiometryNuclear medicinebusiness

description

This study investigates the dosimetric feasibility of Boron Neutron Capture Therapy (BNCT) of explanted livers in the thermal column of the research reactor in Mainz. The Monte Carlo code MCNP5 is used to calculate the biologically weighted dose for different ratios of the (10)B-concentration in tumour to normal liver tissue. The simulation results show that dosimetric goals are only partially met. To guarantee effective BNCT treatment the organ has to be better shielded from all gamma radiation.

yearjournalcountryeditionlanguage
2010-08-05Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2011.08.008