6533b7d2fe1ef96bd125f629
RESEARCH PRODUCT
Growth rate controls mRNA turnover in steady and non-steady states.
José E. Pérez-ortínKevin TrouléSebastián ChávezJosé García-martínezsubject
0301 basic medicineRNA StabilitySaccharomyces cerevisiaeSaccharomyces cerevisiaeyeastTranscriptome03 medical and health sciencesTranscription (biology)Gene Expression Regulation FungalGene expressionmRNA stabilityGrowth rateRNA MessengerMolecular BiologyGenePoint of ViewMessenger RNAbiologyRNA FungalCell Biologybiology.organism_classificationMolecular biologyYeastCell biology030104 developmental biologygrowth rateGene expressiontranscriptiondescription
Gene expression has been investigated in relation with growth rate in the yeast Saccharomyces cerevisiae, following different experimental strategies. The expression of some specific gene functional categories increases or decreases with growth rate. Our recently published results have unveiled that these changes in mRNA concentration with growth depend on the relative alteration of mRNA synthesis and decay, and that, in addition to this gene-specific transcriptomic signature of growth, global mRNA turnover increases with growth rate. We discuss here these results in relation with other previous and concurrent publications, and we add new evidence which indicates that growth rate controls mRNA turnover even under non-steady-state conditions. Ministerio de Economía, Industria y Competitividad BFU2013-48643-C3-3-P Ministerio de Economía, Industria y Competitividad BFU2013-48643-C3-1-P Unión Europea Fondos FEDER Generalitat Valenciana PROMETEO II 2015/006 Junta de Andalucía P12-BIO1938MO
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 | RNA biology |