6533b7d2fe1ef96bd125f6c3
RESEARCH PRODUCT
Phytochemical composition, anti-inflammatory and antitumour activities of four Teucrium essential oils from Greece
Filomena ConfortiFranco PiozziDaniela RiganoCarmen FormisanoFelice SenatoreFederica Menichinisubject
Teucrium brevifolium Teucrium flavum Teucrium montbretii ssp heliotropiifolium Teucrium polium ssp capitatum Lamiaceae Essential oil Sesquiterpene Anti-inflammatory activity CytotoxicitybiologyTraditional medicinemedicine.drug_classCaryophyllenefood and beveragesGeneral Medicinebiology.organism_classificationSesquiterpeneTeucrium poliumAnti-inflammatoryfood.foodAnalytical Chemistrylaw.inventionTeucriumchemistry.chemical_compoundfoodchemistrylawBotanymedicineLamiaceaeCarvacrolEssential oilFood Sciencedescription
Abstract The essential oils of four Teucrium species were studied and 150 components, in all, were identified. All oils were rich in sesquiterpenes (50.1–55.8%). Spathulenol and δ-cadinene were the main compounds of Teucrium brevifolium oil; caryophyllene and 4-vinyl guaiacol predominated in Teucrium flavum . Carvacrol and caryophyllene oxide predominated in Teucrium montbretii ssp. heliotropiifolium , while carvacrol and caryophyllene were the most abundant components in Teucrium polium ssp. capitatum . The oil which most effectively inhibited LPS-induced NO production in macrophage cell line RAW 264.7 was that from T. brevifolium (IC 50 = 7.1 μg/ml), followed by T. montbretii ssp. heliotropiifolium and T. polium ssp. capitatum (IC 50 = 16.5 and 29.4 μg/ml, respectively). The in vitro cytotoxic assay on three human cancer cell lines showed that the most antiproliferative oils were those from T. polium ssp. capitatum and T. montbretii ssp. heliotropiifolium on CACO-2 cell lines (IC 50 = 52.7 and 92.2 μg/ml, respectively). The T. brevifolium oil showed a selective cytotoxicity on COR-L23 while significant activity was exerted by T. polium oil on C32.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-07-15 |