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RESEARCH PRODUCT
ChemInform Abstract: Enantioselective α-Alkylation of Unsaturated Carboxylic Acids Using a Chiral Lithium Amide.
Eva M. BrunSalvador GilMargarita Parrasubject
Lithium amideorganic chemicalsfungiDiastereomerEnantioselective synthesisfood and beveragesHalideGeneral MedicineAlkylationchemistry.chemical_compoundchemistrypolycyclic compoundsOrganic chemistryheterocyclic compoundsEnantiomerdescription
Abstract The regio- and stereochemistry of the alkylation of dienediolates from unsaturated carboxylic acids with benzylic halides, which often results in mixtures of isomers, can be controlled by means of changes in the lithium amide, allowing the α-regioisomer to be obtained as the major diastereoisomer. In addition, when chiral amines are used, moderate enantiomeric excesses can be attained.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-24 | ChemInform |