6533b7d3fe1ef96bd126029c

RESEARCH PRODUCT

Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains.

Nuruddinkodja ZakirkhodjaevMaría ContelYozane HokaiBoruch JurkowiczJacob Fernández-gallardoMercedes SanaúTheodore R. Muth

subject

Methicillin-Resistant Staphylococcus aureusStaphylococcus aureusAuranofinMicrobial Sensitivity Testsmedicine.disease_causeCrystallography X-RayBiochemistryArticleMicrobiologyInorganic ChemistryAuranofinmedicineHumansInhibitory effectbiologyChemistryAntimicrobialbiology.organism_classificationMethicillin-resistant Staphylococcus aureusKidney cellAnti-Bacterial AgentsHEK293 CellsStaphylococcus aureusOrganogold CompoundsBacteriamedicine.drug

description

A series of new heterometallic gold(I) thiolates containing ferrocenyl-phoshines were synthesized. Their antimicrobial properties were studied and compared to that of FDA-approved drug, auranofin (Ridaura), prescribed for the treatment of rheumatoid arthritis. MIC in the order of one digit micromolar were found for most of the compounds against Gram-positive bacteria Staphylococcus aureus and CA MRSA strains US300 and US400. Remarkably, auranofin inhibited S. aureus, US300 and US400 in the order of 150-300 nM. This is the first time that the potent inhibitory effect of auranofin on MRSA strains has been described. The effects of a selected heterometallic compound and auranofin were also studied in a non-tumorigenic human embryonic kidney cell line (HEK-293).

yearjournalcountryeditionlanguage
2014-02-13Journal of inorganic biochemistry
10.1016/j.jinorgbio.2014.05.008https://pubmed.ncbi.nlm.nih.gov/24935090