6533b7d3fe1ef96bd1260851
RESEARCH PRODUCT
4-[5-(4-Fluorophenyl)-3-isopropylisoxazol-4-yl]pyridin-2(1H)-one
Christian PeiferDieter SchollmeyerKatrin KinkelStefan LauferMohammed Abadlehsubject
Hydrogen bondBiological activityGeneral ChemistryCrystal structureCondensed Matter PhysicsMedicinal chemistryTautomerchemistry.chemical_compoundchemistryPyridineLactamGeneral Materials ScienceIsoxazoleIsopropyldescription
The crystal structure of the title compound, C17H15FN2O2, was determined as part of a study of the biological activity of pyridine-substituted isoxazole derivatives as mitogen-activated protein kinase (MAPK) inhibitors. In the crystal structure of the title compound, the compound exists in the lactam and not in the tautomeric pyridin-2-ol form. As the aromatic pyridine nitrogen is considered to be important for accepting a hydrogen bond from p38MAPK, the structure of the lactam unit is correlated with the loss of biological activity of the title compound in the p38MAPK assay. In the crystal structure, the lactam is involved in hydrogen bonds, forming chains along the b axis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-02-23 | Acta Crystallographica Section E Structure Reports Online |