6533b7d3fe1ef96bd1260b68
RESEARCH PRODUCT
Multicellular Interactions in 3D Engineered Myocardial Tissue
Maedeh ZamaniMaedeh ZamaniEsra KaracaEsra KaracaEsra KaracaNgan F. HuangNgan F. HuangNgan F. Huangsubject
0301 basic medicinelcsh:Diseases of the circulatory (Cardiovascular) systemMini Reviewcardiomyocyte02 engineering and technologyDiseaseCardiovascular MedicineBiologyengineered myocardiumfibroblast03 medical and health sciencesParacrine signallingcardiovascular tissue engineeringMyocardial tissueTranslation (biology)021001 nanoscience & nanotechnologyco-culture3. Good healthCell biologystem cellEndothelial stem cellMulticellular organism030104 developmental biologylcsh:RC666-701endothelial cellStem cell0210 nano-technologyCardiology and Cardiovascular MedicineFunction (biology)description
Cardiovascular disease is a leading cause of death in the US and many countries worldwide. Current cell-based clinical trials to restore cardiomyocyte (CM) health by local delivery of cells have shown only moderate benefit in improving cardiac pumping capacity. CMs have highly organized physiological structure and interact dynamically with non-CM populations, including endothelial cells and fibroblasts. Within engineered myocardial tissue, non-CM populations play an important role in CM survival and function, in part by secreting paracrine factors and cell-cell interactions. In this review, we will summarize the progress of engineering myocardial tissue with pre-formed physiological multicellular organization, and will present the challenges towards clinical translation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-10-23 | Frontiers in Cardiovascular Medicine |