6533b7d3fe1ef96bd1260baf

RESEARCH PRODUCT

3-acetylaltholactone and related styryl-lactones, mitochondrial respiratory chain inhibitors.

Eva PerisDiego CortesErnesto EstornellAlmudena BermejoNuria Cabedo

subject

Models MolecularStereochemistryChemical structureSubmitochondrial ParticlesMolecular ConformationPlant ScienceHorticultureBiochemistryMitochondria HeartStyrenesLactonesOxygen ConsumptionAnimals3-acetylaltholactoneCytotoxicityFuransMolecular BiologyGoniothalamusStem barkPlants MedicinalbiologyMolecular StructurePlant StemsUncoupling AgentsGeneral Medicinebiology.organism_classificationNADKineticsMitochondrial respiratory chainAnnonaceaePyronesvisual_artvisual_art.visual_art_mediumBarkCattle

description

A novel furano-pyrone, 3-acetylaltholactone, and two other known styryl-lactones, altholactone and 5-acetoxyisogoniothalamin oxide, have been isolated from Goniothalamus arvensis (Annonaceae) stem bark. We report here the isolation and structural elucidation of these compounds with furane-pyrone and styryl-pyrone skeletons, postulating also for the first time their mechanism of cytotoxicity based on inhibition on mammalian mitochondrial respiratory chain.

yearjournalcountryeditionlanguage
2000-06-01Phytochemistry
10.1016/s0031-9422(00)00104-7https://pubmed.ncbi.nlm.nih.gov/10870186