6533b7d3fe1ef96bd1260c99
RESEARCH PRODUCT
Phage Therapy in Livestock and Companion Animals
Pilar Domingo-calapCelia Ferriol-gonzálezsubject
0301 basic medicineMicrobiology (medical)phage therapyPhage therapyCoronavirus disease 2019 (COVID-19)Phage therapymedicine.drug_classAnimal feedVeterinary medicineCompanion animalmedicine.medical_treatment030106 microbiologyAntibioticsRM1-950ReviewBiologyAntimicrobial resistanceBiochemistryMicrobiologyantibiotics03 medical and health sciencesHealth problemsAntibiotic resistanceAntibioticsmedicinePharmacology (medical)antimicrobial resistanceGeneral Pharmacology Toxicology and Pharmaceuticsbusiness.industryBiotechnologyveterinary medicine030104 developmental biologyInfectious DiseasesLivestockTherapeutics. Pharmacologybusinessdescription
The irrational use of antibiotics has led to a high emergence of multi-drug resistant (MDR) bacteria. The traditional overuse of antibiotics in the animal feed industry plays a crucial role in the emergence of these pathogens that pose both economic and health problems. In addition, antibiotics have also recently experienced an increase to treat companion animal infections, promoting the emergence of MDR bacteria in pets, which can reach humans. Phages have been proposed as an alternative for antibiotics for the treatment of livestock and companion animal infections due to their multiple advantages as adaptative drugs, such as their ability to evolve, to multiply at the site of infections, and their high specificity. Moreover, phage-derived enzymes may also be an interesting approach. However, the lack of regulation for this type of pharmaceutical hinders its potential commercialization. In this review, we summarize the main recent studies on phage therapy in livestock and companion animals, providing an insight into current advances in this area and the future of treatments for bacterial infections.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 | Antibiotics |