6533b7d3fe1ef96bd126162b
RESEARCH PRODUCT
Association between hypovitaminosis D and systemic sclerosis: True or fake?
Giulia BivonaLuisa AgnelloConcetta ScazzoneMarcello CiaccioBruna Lo SassoA. PivettiSalvatore Milanosubject
0301 basic medicinemedicine.medical_specialtyClinical BiochemistryVitamin D Systemic Sclerosis Hypovitaminosis D AutoimmunityDiseasemedicine.disease_causeBiochemistryCalcitriol receptorAutoimmunityPathogenesis03 medical and health sciences0302 clinical medicineHypovitaminosisDLCOInternal medicinemedicineVitamin D and neurologyHumansVitamin D030203 arthritis & rheumatologyScleroderma Systemicbusiness.industryBiochemistry (medical)General MedicineVitamin D Deficiency030104 developmental biologyImmunologybusinessHormonedescription
Abstract Background Vitamin D insufficiency/deficiency is considered a major factor triggering and enhancing several autoimmune disorders; hypovitaminosis D has been reported to be common in Systemic Sclerosis (SSc). Previous studies assessing vitamin D insufficiency/deficiency in SSc have been reviewed, and the relation with pathogenesis and clinical features has been examined. Content Eligibility criteria were: reporting measurement of Vitamin D serum levels in all participants and evaluating adult onset-SSc individuals as patients group. Results: The association between clinical features and low hormone levels is controversial. Manifold data have shown vitamin D insufficiency/deficiency to have a potential role in the pathogenesis of disease, providing inconclusive findings. Summary Promoting the onset of SSc depends on the interaction between genetics, environment and infections. It remains a sound question whether Vitamin D insufficiency/deficiency is an environment-linked immunological heckler, making infectious agents taking root.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-07-01 |