6533b7d3fe1ef96bd1261676
RESEARCH PRODUCT
Voila, a New Drosophila Courtship Variant that Affects the Nervous System: Behavioral, Neural, and Genetic Characterization
Maria BalakirevaNanaë GendreReinhard F. StockerJean-françois Ferveursubject
Nervous systemMaleGene ExpressionGenes InsectPheromonesWing0302 clinical medicineWings AnimalDrosophila melanogaster/*geneticsGene Expression/physiologyGenetics0303 health sciencesbiologyGeneral NeuroscienceInsect physiologyChromosome MappingInsect/*physiologyPhenotypemedicine.anatomical_structurePeripheral Nervous System/chemistryDrosophila melanogasterLac OperonPeripheral nervous systemMushroom bodiesFemaleDrosophila melanogasterTransgeneArticleChromosomesBrain Chemistry/physiology03 medical and health sciencesDNA Transposable Elements/physiologyPeripheral Nervous SystemmedicinePheromones/physiologyAnimalsGene030304 developmental biologyBrain ChemistryCourtshipExtremitiesSex Determination Processesbiology.organism_classificationGanglia InvertebrateInvertebrate/chemistryGenesDNA Transposable ElementsSex Determination (Genetics)Ganglia030217 neurology & neurosurgerydescription
InDrosophila melanogaster, a specificPGAL4transposon induces theVoila1genetic variant and produces multiple phenotypes. HomozygousVoila1/1flies rarely reach adulthood, whereas heterozygousVoila1/+adult males show strong bisexual behavior. Males with a single copy ofVoila1driving the feminizing transgeneUAS-transformershow very reduced sexual activity but no overall effect on their behavior.Voila1is specifically expressed in the nervous system. In the CNS, it is expressed mainly in the mushroom bodies and, to a lesser extent, in the antennal lobes. In the peripheral nervous system, GAL4 expression is almost entirely restricted to the gustatory sensilla. Using chromosomal deficiencies, the behavioral alteration was genetically mapped to the same location as thePGAL4element (86E1–2). The multiple behavioral effects of theVoilagenetic variant are discussed in light of its expression in the nervous system and its genetic basis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-06-01 |