6533b7d4fe1ef96bd1261c38

RESEARCH PRODUCT

Gene Expression and Epigenetic Signatures of Germ Cell-Derived Pluripotent Stem Cells and Embryonic Stem Cells

Ulrich ZechnerD. V. Krishna PantakaniHassan DihaziJessica Nolte

subject

Homeobox protein NANOG0303 health sciencesTetraploid complementation assay030302 biochemistry & molecular biologyEmbryoid bodyBiologyEmbryonic stem cell3. Good healthCell biology03 medical and health sciencesStem cellInduced pluripotent stem cellReprogramming030304 developmental biologyAdult stem cell

description

Germ cell-derived Pluripotent Stem Cells (gPSCs) are pluripotent stem cells that originate from Spermatogonial Stem Cells (SSCs) of the testis. Several reports in the last few years have shown that it is possible to isolate and enrich the SSC population by different approaches and even reprogram these in vivo multipotent cells to gPSCs in vitro. As these cells could be an alternative to circumvent the ethical objections regarding the use of Embryonic Stem Cells (ESCs) for therapeutic approaches, these SSC-derived gPSCs were characterized in several studies comparatively to the gold standard of pluripotency, the ESCs. The results ­provide great promise that gPSCs can be of importance for practical use in regenerative medicine.

yearjournalcountryeditionlanguage
2012-01-01
https://doi.org/10.1007/978-94-007-2993-3_3