6533b7d4fe1ef96bd1261c65
RESEARCH PRODUCT
Tuneable pH-regulated supramolecular copolymerisation by mixing mismatched dendritic peptide comonomers
Hendrik FrischHendrik FrischPol BeseniusPatrick AhlersPatrick Ahlerssubject
chemistry.chemical_classificationchemistry.chemical_compoundPolymers and PlasticsChemistryComonomerOrganic ChemistryPolymer chemistryCopolymerSupramolecular chemistryBioengineeringPeptideBiochemistryMixing (physics)description
Charged phenylalanine-rich dendritic peptides form highly stable and pH-switchable rod-like supramolecular copolymers, when co-assembled with a matching oppositely charged dendritic comonomer. Here, we demonstrate that by mismatching a strong with a weak β-sheet encoded comonomer, both the stability and the pH-triggered disassembly of the copolymers shifts drastically from pH 4.2 to biologically relevant pH 5.8.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | Polymer Chemistry |