6533b7d4fe1ef96bd1261ed9
RESEARCH PRODUCT
Secondary Structure-Driven Hydrogelation Using Foldable Telechelic Polymer-Peptide Conjugates.
Ronja OtterSebastian SeiffertTobias BauerPol BeseniusNina Alexandra HenkeMatthias BarzChristian M. Beracsubject
Polymers and PlasticsPolymersSurface PropertiesSupramolecular chemistryPeptide02 engineering and technology010402 general chemistry01 natural sciencesPentapeptide repeatMaterials ChemistryParticle SizeProtein secondary structurechemistry.chemical_classificationTelechelic polymerMolecular StructurefungiOrganic Chemistrytechnology industry and agriculturefood and beveragesHydrogelsHydrogen-Ion Concentration021001 nanoscience & nanotechnologyCombinatorial chemistry0104 chemical sciencesFolding (chemistry)Supramolecular polymerschemistrySelf-healing hydrogels0210 nano-technologyPeptidesdescription
The synthesis of ABA and ABA' triblock polyethylene glycol-and polysarcosine-peptide conjugates is reported. The A/A' peptides are based on phenylalanine(F)-histidine(H) pentapeptide sequences FHFHF, which promote pH-switchable β-sheet self-assembly into nanorods in water. Only parallel β-sheet-driven folding and intermolecular assembly using ABA triblock polymer-peptide conjugates leads to interstrand cross-linking and hydrogelation, highlighting the impact of supramolecular interactions-directed structure formation at the nano- and mesoscopic level.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-07-24 | Macromolecular rapid communications |