6533b7d4fe1ef96bd1261fe7
RESEARCH PRODUCT
Organocatalytic enantioselective Mannich reaction of isoxazol-5(4H)-ones to isatin-derived ketimines
Ricardo ToránDario PuchánAmparo Sanz-marcoCarlos VilaJosé R. PedroGonzalo Blaysubject
Compostos heterocíclicsCatàlisiOrganic ChemistryPhysical and Theoretical ChemistryBiochemistryQuímica orgànicadescription
An efficient organocatalytic asymmetric Mannich reaction between isoxazol-5(4H)-ones and isatin-derived ketimines has been developed. A bifunctional squaramide/Brønsted base organocatalyst catalyzed the enantioselective Mannich addition to afford chiral 3-aminooxindoles bearing a tetrasubstituted stereocenter at C3 decorated with an isoxazole moiety in good yields and with excellent enantioselectivities. Additionally, several synthetic transformations were described showing the versatility of the prepared compounds.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-01-01 |