6533b7d4fe1ef96bd1261ffe

RESEARCH PRODUCT

Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa

Marialuisa MennaSanja Perović-ottstadtAnna AielloMonica D’espositoWerner E.g. MüllerErnesto FattorussoHeinz C. Schröder

subject

SerotoninSpectrometry Mass Electrospray Ionizationendocrine systemAxinella verrucosaMagnetic Resonance SpectroscopyStereochemistryClinical BiochemistryThin layerGlutamic AcidPharmaceutical ScienceSpectrometry Mass Fast Atom BombardmentPharmacognosycomplex mixturesBiochemistryAnimal originPyrrole derivativesNatural productCell LineAlkaloidsBromopyrrole alkaloidDrug DiscoveryAnimalsPyrrolesheterocyclic compoundsMolecular BiologyNeuronsMarine spongeMolecular StructurebiologyChemistryorganic chemicalsAlkaloidOrganic ChemistryQuisqualic AcidBiological activitybiology.organism_classificationPoriferaSpongeNeuroprotective activity.Axinella verrucosaMolecular MedicineCalciumChromatography Thin LayerSerotonin AntagonistsExcitatory Amino Acid Antagonists

description

The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5-18, four novel alkaloids of this class, compounds 1-4, have been isolated, and their structures established through spectroscopic methods. Compounds 1-4 were found to display neuroprotective activity against the agonists serotonin and glutamate in vitro.

yearjournalcountryeditionlanguage
2005-05-26
10.1016/j.bmc.2005.07.057http://hdl.handle.net/11588/200756