Augu vīrusa RGMoV nestrukturālo proteīnu raksturošanas pētījumi

6533b7d4fe1ef96bd1262244

RESEARCH PRODUCT

Augu vīrusa RGMoV nestrukturālo proteīnu raksturošanas pētījumi

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Darba mērķis ir veikt funkcionālu un strukturālu RGMoV nestrukturālo proteīnu raksturojumu, izmantojot E.coli ekspresijas sistēmu rekombinantu proteīnu iegūšanai. Darba gaitā tika izveidotas vairākas E.coli ekspresijas plazmīdu konstrukcijas, kas satur RGMoV nestrukturālos proteīnus kodējošus gēnus – RdRP, P1, SerP-VPg un P10. Iegūtas poliklonālās peļu antivielas pret sajūgto proteīnu Rbx-P1. Iegūti preparatīvos daudzumos, šķīstošā formā rekombinanti SerP-VPg un P10, tiem veikti kristalizācijas eksperimenti, kuros noskaidroti P10 kristalizācijas apstākļi. Veikta ATFāzes aktivitātes noteikšana rekombinantajiem P10, P16. Darbs izstrādāts Latvijas Biomedicīnas pētījumu un studiju centrā Rekombinanto proteīnu laboratorijā Dr.biol. Andra Zeltiņa, Dr.biol. Inas Baļķes vadībā, laika posmā laika posmā 2011.10.-2013.05. Atslēgas vārdi: nestrukturālie RGMoV proteīni, proteīnu funkcionāls un strukturāls raksturojums, Sobemovirus, kristalogrāfija, E.coli ekspresijas sistēma.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/26885

PEPhysical Sciences and Engineering
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