6533b7d4fe1ef96bd12626ab

RESEARCH PRODUCT

Macromolecules in ordered media. 6. Effect of the phospholipidic bilayer composition on poly (2-vinyl pyridine) - liposome association

Rosa GarcíaVicente SoriaConcepción AbadIolanda PorcarAgustín Campos

subject

LiposomePolymers and PlasticsBilayerOrganic ChemistrySynthetic membranePhospholipidCondensed Matter PhysicsPolyelectrolyteCrystallographychemistry.chemical_compoundMembranechemistryMaterials ChemistryOrganic chemistryLipid bilayerMacromolecule

description

The intrinsic fluorescence emission of poly (2-vinyl pyridine) has been exploited in order to gain insight into the nature of the interaction with artificial membranes. In this contribution, the study has been focused on the effect of the phospholipid bilayer composition on the association to the polymer. Fluorescence data have been converted into association isotherms and then analyzed in terms of both binding and partition models. Results show that the association is enhanced by the presence of negative charged phospholipid as a constituent of the liposomal membrane. The strong surface density dependence of the polymer-liposome association indicatesthe predominantly electrostatic nature of that interaction.

https://doi.org/10.1002/masy.19971190125