6533b7d4fe1ef96bd126271c

RESEARCH PRODUCT

Wirkung und Wechselwirkung von Theophyllin und Chinin auf die neuromuskuläre Übertragung und die elektromechanische Kopplung am M. gastrocnemius

G. BöhmerH. R. O. Dinse

subject

Quininemedicine.medical_specialtyContraction timeEndocrinologyChemistryInternal medicinemedicineStimulationTheophyllinemedicine.symptomRate of risemedicine.drugMuscle cramp

description

It has been reported that theophylline improves the effect of quinine in relieving patients from nocturnal muscle cramps. We therefore examined the actions and interactions of quinine and theophylline on mechanical and electrical properties of the rabbit’s N. ischiadicus — M. gastrocnemius nerve-muscle preperation in situ. Maximal tension, rate of rise of tension, contraction time, relaxation time and latency of single maximal twitch, evoked by electrical stimulation of N. ischiadicus were measured before and after i.p. or iv. application of therapeutic doses of quinine and theophylline given alone or in combination. In addition, changes of conduction velocities of action potentials of the ischiadic nerve or M. gastrocnemius were determined.

yearjournalcountryeditionlanguage
1982-01-01
https://doi.org/10.1007/978-3-663-05268-5_16