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RESEARCH PRODUCT
Extraction of lapachol from Tabebuia avellanedae wood with supercritical CO2: an alternative to Soxhlet extraction?
Wolfram BaumannL. M. VianaMarcos R. G. De FreitasSilvana Vianna Rodriguessubject
lapacholChromatographyChemistrysolubilityGeneral Chemical EngineeringExtraction (chemistry)Supercritical fluid extractionlcsh:TP155-156Tabebuia avellanedaeextractabilitySupercritical fluidAutoclavechemistry.chemical_compoundDehydro-alpha-lapachonedehydro-alpha-lapachonesupercriticalCO2lapachonelcsh:Chemical engineeringSolubilityLapacholdescription
The solubility of lapachol in supercritical CO2 was determined at 40°C and pressures between 90 and 210 bar. Supercritical fluid extraction of lapachol and some related compounds by CO2 from Tabebuia avellanedae wood is compared to Soxhlet extraction with different solvents. A standard macroscale (100-200 g wood) and a microscale (~10 mg wood) experimental setup are described and their results are compared. The latter involved direct spectrophotometric quantification in a high-pressure autoclave with an integrated optical path and a magnetic stirrer, fitted directly into a commercial spectrophotometer. The relative amount of lapachol extracted by supercritical CO2 at 40°C and 200 bar was about 1.7%, which is similar to the results of Soxhlet extractions. Lower contents of alpha- and beta-lapachone as well as dehydro-alpha-lapachone are also reported.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-09-01 | Brazilian Journal of Chemical Engineering |