6533b7d4fe1ef96bd1262a9a

RESEARCH PRODUCT

Persistent unilateral tibialis anterior muscle hypertrophy with complex repetitive discharges and myalgia

Hanns Christian HopfS. RoontgaIan J. ButlerWilfred NixLudwig Gutmann

subject

AdultMalemyalgiamedicine.medical_specialtyBotulinum ToxinsAnterior tibial muscleMuscle volumemedicine.disease_causeInjections IntramuscularMuscle hypertrophyBotulinum toxin aMuscular DiseasesTibialis anterior musclemedicineHumansLegbusiness.industryMusclesHypertrophyMiddle AgedBotulinum toxinSurgeryAnesthesiaClostridium botulinumNeurology (clinical)medicine.symptombusinessmedicine.drug

description

Unilateral enlargement of the tibialis anterior muscle associated with complex repetitive discharges occurred over several months in two patients and was preceded by pain and numbness in the lower leg. Neuroradiologic investigations excluded a compressive radiculopathy, but pharmacologic and neurophysiologic studies suggested a neurogenic basis for the muscle hypertrophy. Botulinum toxin A injection into the hypertrophied muscles led to a decreased muscle volume and cessation of muscle pain.

yearjournalcountryeditionlanguage
1992-03-01Neurology
https://doi.org/10.1212/wnl.42.3.602