6533b7d4fe1ef96bd12631ff
RESEARCH PRODUCT
Production of T suppressor factor specific for the hapten picryl chloride requires both T suppressor cells and an antigen-specific, genetically restricted second signal
Alfredo SalernoG Colonna RomanoFrancesco DieliDomenico Liosubject
MaleMice Inbred StrainsPicryl ChlorideBiologyT-Lymphocytes Regulatorylaw.inventionPicryl chlorideEpitopesMicechemistry.chemical_compoundInterleukin 21AntigenlawSuppressor Factors ImmunologicAnimalsCytotoxic T cellDisulfidesCells CulturedGeneral Environmental ScienceH-2 AntigensLymphokineGeneral MedicineT lymphocyteCell biologychemistryImmunologyGeneral Earth and Planetary SciencesSuppressorFemaleHaptensOxidation-ReductionHaptenSpleendescription
Summary We investigated the requirement for activation of T suppressor cells specific for the hapten picryl chloride and the release of hapten-specific T suppressor factor. Using an in vivo experimental system, we report that activation of T suppressor cells and the consequent release of T suppressor factor required two signals: one was provided by primed T suppressor cells, i.e. spleen cells from mice injected with the tolerogen picrylsulphonic acid, and the other was provided by the specific antigen in the context of H-2 gene products. Mechanisms by which the interaction between these two signals led to activation of T suppressor cells and the production of T suppressor factor, as well as a comparison with other antigen-specific suppressor systems, are discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-11-01 | Annales de l'Institut Pasteur / Immunologie |